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Postdoctoral Scholar in Intestinal Innate Immunity and Host Defense Peptides, Faculty of Veterinary Medicine

Job ID: 17816

Updated: June 7, 2019

Location: 

Position Description

Area:   Immunology (Medicine and Veterinary Medicine)
Duration:   1 year in the first instance with funding available for up to three years 
Start date:   As soon as possible
Salary:   $ 40,000/year plus Plan C benefits. 

Dr. Eduardo Cobo in the Faculty of Veterinary Medicine at the University of Calgary is accepting applications for a Postdoctoral Scholar in Gastroenterology and Innate Immunity

Job Description:

One post-doctoral position is available immediately at University of Calgary, Canada to study the gut innate immunity contributed by host defense peptides and immunoregulation in the epithelial and leukocyte cross-talking in response to microbial pathogens. The Cobo lab is located at the Foothills campus of the University of Calgary and is part of the large and interactive Snyder Institute for Chronic Diseases, Inflammation Research Network and Infection Biology groups. Mentoring and collaboration are core values across the medicine, biology and veterinary faculties, providing an excellent environment for postdoctoral training. 

The lab investigates antimicrobial and immune modulatory functions of host defense (cathelicidin and defensin) peptides innately secreted by the intestinal epithelium and surrounding neutrophils in intestinal homeostasis and disease. These peptides are important components of the epithelial innate immune system, with still unknown roles controlling infection and mitigating inflammatory responses. They are increasingly interesting as novel therapeutic alternatives to conventional antibiotics. The successful candidate will work with Dr. Cobo to determine the role of cathelicidins promoting neutrophil and macrophage defenses in the gut when infected by pathogens (special emphasis in Salmonella, Cryptosporidium and Brachyspira) and explore new roles of host defense peptides in the gut mucin barrier. The lab has established several models of infection in cultured intestinal cells and leukocytes, advanced 3-dimensional culture organoids systems and murine models deprived of cathelicidins to determine mechanisms of action of cathelicidins and defensins. Findings are further studied in large animal models (e.g., pigs and calves). Cutting-edge immunology tools, including flow cytometry and genome-wide expression analyses combined with state-of-the-art microscopy to identify correlates of immune protection and pathways of immune regulation in gut protection are routinely used.

The lab culture is highly collaborative and in addition to leading their own project, the postdoctoral fellow will have opportunities to contribute to other team projects in the lab related with skin and mammary gland innate immunology. The candidate will also develop and participate in external collaborations, and in mentoring of students and junior lab members as part of career development. Opportunities for international travel, including to collaborating sites in China and France, will be available. Additional professional development opportunities will be available through our Postdoctoral office https://research.ucalgary.ca/postdocs

Qualifications:

  • A highly motivated candidate with a Ph.D. (in the last 3 years) in immunology, molecular biology, or a relevant discipline.
  • Be able to work independently and in a collaborative team.
  • Strong communication skills in English, both written and spoken.
  • Proven track record in academic research in immunology, infectious diseases or a related subject area in the context of innate immunity and gastroenterology.
  • Hands-on expertise in mouse models and cell culture, ideally including the study of gene/protein determination and microscopy.
  • Expertise with flow cytometry and RNAseq (library prep, bioinformatic analysis) is strongly preferred. 

Application details:  

For further information about this position, please contact:

Dr. Eduardo Cobo
Email: ecobo@ucalgary.ca
Phone: +1 (403) 210-7247
Cobo Lab Website: https://www.ucalgary.ca/cobolab/

Interested applicants should apply by email to the above investigator and include a 1) Cover Letter describing the motivation for this position, 2) a detailed CV, 3) a description of the research expertise and 4) the names and contact details of 2 referees.

The University of Calgary recognizes that a diverse staff/faculty benefits and enriches the work, learning and research experiences of the entire campus and greater community. We are committed to removing barriers that have been historically encountered by some people in our society. We strive to recruit individuals who will further enhance our diversity and will support their academic and professional success while they are here. All qualified candidates are encouraged to apply; however Canadians and permanent residents will be given priority. In this connection, at the time of your application, please answer the following question: Are you a Canadian citizen or a permanent resident of Canada? (Yes/No)

Additional Information

To learn more about postdoctoral scholar opportunities at the University of Calgary and all we have to offer, view our Postdoc Careers website. For more information about the Faculty of Veterinary Medicine visit Careers in the Faculty of Veterinary Medicine.

About the University of Calgary

The University of Calgary is Canada’s leading next-generation university – a living, growing and youthful institution that embraces change and opportunity with a can-do attitude. Located in the nation’s most enterprising city, the university is making tremendous progress on its Eyes High journey to be recognized as one of Canada’s top five research universities, grounded in innovative learning and teaching and fully integrated with the community it both serves and leads. The University of Calgary inspires and supports discovery, creativity and innovation across all disciplines. For more information, visit ucalgary.ca.

To succeed as one of Canada’s top universities, where new ideas are created, tested and applied through first-class teaching and research, the University of Calgary needs more of the best minds in our classrooms and labs. We’re increasing our scholarly capacity by investing in people who want to change the world, bringing the best and brightest to Calgary to form a global intellectual hub and achieve advances that matter to everyone.

About Calgary, Alberta

Calgary is one of the world's cleanest cities and has been named one of the world's most livable cities for years. Calgary is a city of leaders – in business, community, philanthropy and volunteerism. Calgarians benefit from the strongest economy in the nation and enjoy more days of sunshine per year than any other major Canadian city. Calgary is less than an hour’s drive from the Rocky Mountains and boasts the most extensive urban pathway and bikeway network in North America.

The University of Calgary recognizes that a diverse staff/faculty benefits and enriches the work, learning and research experiences of the entire campus and greater community. We are committed to removing barriers that have been historically encountered by some people in our society. We strive to recruit individuals who will further enhance our diversity and will support their professional success while they are here. We encourage all qualified applicants to apply, however preference will be given to Canadian citizens and permanent residents of Canada.

 

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