Bioinfomatician, Arnie Charbonneau Cancer Institute, Cumming School of Medicine

Position Overview

The Arnie Charbonneau Cancer Institute in the Cumming School of Medicine invites applications for a Bioinformatician. This Full-time Fixed Term position is for approximately 1 year (based on length of grant funding), with the possibility of extension.

The Arnie Charbonneau Cancer Institute is participating in a multi-disciplinary translational research program called the Alberta Cellular Therapy and Immune ONcology (ACTION) initiative, which seeks to develop next-generation cellular immunotherapies and deliver them to cancer patients in Alberta and beyond. 

The Bioinformatician will be part of the ACTION team, reporting directly to the Principal Investigator.   

The Primary Purpose of the bioinformatician is to implement and develop workflows for multi-omic datasets generated through ACTION with the goal of identifying immunotherapy targets.

Position Description

Summary of Key Responsibilities (job functions include but are not limited to):

• Implement pipelines for analysis of bulk and single-cell RNAseq datasets
• Perform supervised and unsupervised analyses of expression differences at the gene, exon/isoform, and protein level using in-house and public datasets, using clustering and/or network approaches
• Implement pipelines to detect somatic alterations (including CNA/SVs, SNVs/indels), determine their clonality, and infer tumor phylogenies
• Predict the effect of coding mutations on protein structure and function, including HLA binding
• Integrate genomic, expression, and proteome datasets to identify candidates suitable for further development as cellular therapy targets
• Design and execute moderately complex in silico experiments with minimal supervision
• Maintain clear and accurate documentation
• Disseminate results through conference presentations and publications
• Establish and maintain effective and productive relationship with other members of Charbonneau and ACTION, and contribute to training of junior team members
• Provide accurate and timely milestone reports in accordance with project objectives and deliverables

Qualifications / Requirements:

• Graduate degree Bioinformatics, Computer Science, Molecular Biology, or related field required.  MSc required, PhD preferred
• Proficiency in at least one programming language (such as Python or R)
• Experience with Linux / Unix working environments
• Previous experience working on a high-performance computing cluster an asset
• Expertise with analysis and algorithm development on complex NGS datasets
• Excellent oral and written communication skills
• Must be able to work both independently and in a team environment
• Ability to exercise judgement within established guidelines
• Intermediate to advanced skills in Microsoft Office Suite (Word, Outlook, Excel, PowerPoint), Internet skills
• Knowledge of University core business systems is desirable

Application Deadline:  August 7, 2020

We would like to thank all applicants in advance for submitting their resumes. Please note, only those candidates chosen to continue on through the selection process will be contacted.

Additional Information

This position is part of the AUPE bargaining unit, and falls under the Technical Job Family, Phase I.

To find out more about management and staff opportunities at the University of Calgary and all we have to offer, view our Management and Staff Careers website. For more information about the Cumming School of Medicine visit Careers in the Cumming School of Medicine.

About the University of Calgary

The University of Calgary is Canada’s leading next-generation university – a living, growing and youthful institution that embraces change and opportunity with a can-do attitude. Located in the nation’s most enterprising city, the university is making tremendous progress on its Eyes High journey to be recognized as one of Canada’s top five research universities, grounded in innovative learning and teaching and fully integrated with the community it both serves and leads. The University of Calgary inspires and supports discovery, creativity and innovation across all disciplines. For more information, visit ucalgary.ca.

The University of Calgary recognizes that a diverse staff/faculty benefits and enriches the work, learning and research experiences of the entire campus and greater community. We are committed to removing barriers that have been historically encountered by some people in our society. We strive to recruit individuals who will further enhance our diversity and will support their professional success while they are here. We encourage all qualified applicants to apply, however preference will be given to Canadian citizens and permanent residents of Canada.