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Postdoctoral Scholar, Physiology & Pharmacology, Cumming School of Medicine

Job ID: 22935

Updated: May 18, 2021

Location: Foothills Campus

We would like to take this opportunity to acknowledge the traditional territories of the people of the Treaty 7 region in Southern Alberta. The City of Calgary is also home to Métis Nation of Alberta, Region III.

Position Description

Area: Proteases, Proteomics, N-terminomics, Systems biology, Bioinformatics, Inflammation, Arthritis.

Duration: 2 years with possibility of renewal extension

Start Date: As soon as possible

Salary: Minimum $50,000 per year plus Plan C health benefits

The Department of Physiology & Pharmacology in the Cumming School of Medicine at the University of Calgary is accepting applications for a Postdoctoral Scholar in Proteases, Proteomics, N-terminomics, Systems biology, Bioinformatics, Inflammation, Arthritis.

Job Description:

Loss of lubricin (Proteoglycan 4) results in decreased joint lubrication and increased cartilage degeneration. This project will elucidate the role of tryptase, a protease that cleaves lubricin within joints. We will test a novel treatment approach for osteoarthritis (OA): a potential combination of recombinant human lubricin with a tryptase inhibitor. The goal is to characterize the mechanisms affected by the loss of joint lubrication to better understand how to reduce chronic and debilitating pain in OA patients and provide drug target validation via preclinical studies using OA animal models. These results will be validated in human synovial fluids and synovial membrane biopsies. This study has the potential to be translatable to other types of arthritis (inflammatory and juvenile arthritis) as lubricin and tryptase also play key roles in these chronic diseases.

New skills that will be acquired working on this project:

N-terminomics/TAILS (Terminal Amino Isotopic Labeling of Substrates), proteomics, phosphoproteomics, bioinformatics analysis of proteomics data, protease biology, proteoglycan biology, cell signaling, animal models of joint inflammation, translational studies using human biopsies, histology.

Qualifications:

  • Graduation from an accredited college or university with a PhD within the past three (3) years.
  • Scientific   background   and   strong    experience   in    protease   biology,   proteomics, bioinformatics, or arthritis research.
  • Excellent communication skills in English.
  • Proven ability to work independently within a research lab.
  • Demonstrated capacity to work effectively in a collaborative and team environment

Application Details:

  • Applicants may send their application in one single PDF file via email directly to Dr. Antoine Dufour ([email protected]).
  • Review of applications will begin July 1st, 2021 and continue until position is filled.
  • Required application materials:
    1. Cover letter (including scientific interests and project ideas)
    2. Resume/Curriculum Vitae
    3. Contact information for 2-3 professional work references

This posting will remain open until a successful candidate is identified. 

What We Offer:

The postdoctoral scholar will be part of a rich academic community which includes the Departments of Psychiatry, Community Health Sciences and, Cumming School of Medicine, University of Calgary. The postdoctoral scholar will be part of the larger University community through engagement in the Hotchkiss Brain Institute. The postdoctoral scholar will participate in weekly team meetings, grand rounds, journal clubs and research seminars where principal investigators, postdoctoral scholars and trainees present their most recent work. They will work in a collaborative multi-disciplinary team made up of researchers, clinicians, postdoctoral scholars, research associates and coordinators, biostatisticians, and trainees at all levels. They will have the opportunity to present their research findings at conferences where they will network with other researchers. And have the opportunity to substantially engage with patients and families, clinicians and decision-makers throughout their research.

Additional Information

To learn more about postdoctoral scholar opportunities at the University of Calgary and all we have to offer, view our Postdoc Careers website. For more information about the Cumming School of Medicine visit Careers in the Cumming School of Medicine.

About the University of Calgary

The University of Calgary is Canada’s leading next-generation university – a living, growing and youthful institution that embraces change and opportunity with a can-do attitude. Located in the nation’s most enterprising city, the university is making tremendous progress on its Eyes High journey to be recognized as one of Canada’s top five research universities, grounded in innovative learning and teaching and fully integrated with the community it both serves and leads. The University of Calgary inspires and supports discovery, creativity and innovation across all disciplines. For more information, visit ucalgary.ca.

To succeed as one of Canada’s top universities, where new ideas are created, tested and applied through first-class teaching and research, the University of Calgary needs more of the best minds in our classrooms and labs. We’re increasing our scholarly capacity by investing in people who want to change the world, bringing the best and brightest to Calgary to form a global intellectual hub and achieve advances that matter to everyone. For more information visit research.ucalgary.ca/postdocs.

About Calgary, Alberta

Calgary is one of the world's cleanest cities and has been named one of the world's most livable cities for years. Calgary is a city of leaders – in business, community, philanthropy and volunteerism. Calgarians benefit from the strongest economy in the nation and enjoy more days of sunshine per year than any other major Canadian city. Calgary is less than an hour’s drive from the Rocky Mountains and boasts the most extensive urban pathway and bikeway network in North America.

The University of Calgary has launched an institution-wide Indigenous Strategy in line with the foundational goals of Eyes High, committing to creating a rich, vibrant, and culturally competent campus that welcomes and supports Indigenous Peoples, encourages Indigenous community partnerships, is inclusive of Indigenous perspectives in all that we do.

The University of Calgary recognizes that a diverse staff/faculty benefits and enriches the work, learning and research experiences of the entire campus and greater community. We are committed to removing barriers that have been historically encountered by some people in our society. We strive to recruit individuals who will further enhance our diversity and will support their professional success while they are here. 

 

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